1. “Crystal structure of the G119S mutant acetylcholinesterase of the malaria vector An. gambiae reveals the basis of insecticide resistance” Jonah Cheung*, Arshod Mahmood, Ravi Kalathur, Lixuan Liu, Paul R. Carlier, Structure 2018, 126, 130-136, PMID: 29276037, DOI:10.1016/j.str.2017.11.021

  2. Select β- and 𝛾-branched 1-alkylpyrazol-4-yl methylcarbamates exhibit high selectivity for inhibition of Anopheles gambiae versushuman acetylcholinesterase. Paul R. Carlier*, Qiao-Hong Chen, Astha Verma, Dawn M. Wong, James M. Mutunga, Jasmin Müller, Alex M. Shimozono, Rafique Islam, Fan Tong,Jianyong Li, Max Totrov,Jeffrey R. Bloomquist, Pesticide Biochemistry and Physiology, 2018, in press,

  3. Biological studies and target-engagement of the 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD)-targeting antimalarial agent (1R,3S)-MMV008138 and analogs. Maryam Ghavami, Emilio F. Merino, Zhong-Ke Yao, Rubayat Elahi, Morgan E. Simpson, Maria L. Fernandez-Murga, Joshua H. Butler, Michael A. Casasanta, Priscilla M. Krai, Maxim M. Totrov, Daniel J. Slade, Paul R. Carlier*, and Maria Belen Cassera*, ACS Infectious Diseases 2018, 4, 549-559. PMID: 29072835, 
    DOI: 10.1021/acsinfecdis.7b00159

  4. Discovery of Species-selective and Resistance-breeaking Anticholinesterase Insecticides for the Malaria Mosquito. Paul R. Carlier*, Jeffrey R. Bloomquist, Max Totrov, and Jianyong Li, invited review, Current Medicinal Chemistry 2017, 24, 2946–2958. DOI: 10.2174/0929867324666170206130024

  5. N'-Mono- and N,N'-diacyl derivatives of benzyl and arylhydrazines as contact insecticides against adult Anopheles gambiae. Joseph S. Celements II, Fan Tong, Baonan Sun, Aaron d. Gross, Rafique Islam, Jeffrey R. Bloomquistb, Paul R. Carlier*, Pesticide Biochemistry and Physiology 2017, 143, 33–38, DOI: 10.1016/j.pestbp.2017.10.001

  6. Parallel inhibition of amino acid efflux and parasite growth of erythrocytic Plasmodium falciparum by mefloquine and non-piperidine analogs: implications for the mechanism of antimalarial action Maryam Ghavami, Christine Dapper, Seema Dalal, Kristina Holzschneider, Michael Klemba, and Paul R. Carlier*, Bioorganic & Medicinal Chemistry Letters 2016, 26, 4846-4850, DOI: 10.1016/j.bmcl.2016.08.005

© 2018 by Paul Carlier

website questions? contact:

  • Facebook Clean Grey
  • Twitter Clean Grey
  • LinkedIn Clean Grey